This study aims to investigate the phenomenon of marginalization and exclusion, which is considered one of the greatest challenges facing the interior regions of Tunisia, albeit to varying degrees. It is noted that this phenomenon has deepened over the last decade. It pushes towards entrenching class, economic, social, and regional disparities. The overall trend of the results of this research revealed that the growth of this phenomenon has led to an increase in social tensions, higher crime rates, and undermined social stability, which in turn affects the economic, social, and political balances of society. We relied on descriptive analytical methods and statistics issued by official entities to diagnose the studied phenomenon and analyze its negative repercussions on all social and economic levels. The importance of this study lies in its findings, which confirm that the Tunisian developmental policy, despite the modifications and reforms it has undergone to keep pace with the economic, social, and political transformations in Tunisian society, has nonetheless maintained its discriminatory and exclusionary nature towards the interior regions of Tunisia. These regions have been deprived of major developmental and investment projects with high employment capacity, while the coastal areas and the capital cities have benefited from such projects. This has resulted in increased poverty rates and unemployment in the interior regions, in contrast to their reduction in the coastal regions and major cities of Tunisia. This will be the focus of our analysis and discussion through our research.