This study examines the interactive relationship between children’s drawings and textile and fashion design. Specifically, it highlights the transformation of childish imagination into meaningful textile patterns and garments. To achieve this objective, a qualitative and experimental approach is adopted, combining semiotic analysis with creative practice. In this respect, children’s drawings are reinterpreted through collage, digital illustration, and artificial intelligence to generate textile and fashion design proposals. The findings indicate that this transformation preserves the expressive spontaneity of children’s drawings while simultaneously enhancing cognitive learning, sensory awareness, and creative interaction. Moreover, digital tools extend the child’s creative gesture and thus enrich their textile translation. Overall, the transition from children’s drawings to textile and fashion design constitutes a semiotic and creative process in which image, material, and technology converge. Consequently, the garment becomes a medium of memory, narration, and sustainable valorization of childish imagination.