This study explores how artistic mediation can be used to support the development of life skills in early childhood. It began with an exploratory phase that examined current practices in the field through a descriptive-analytical approach, followed by an evaluation of an intervention program designed to enhance children’s life skills through diverse forms of artistic mediation. A quasi-experimental design was employed, using a pre- and post-intervention five-point Likert scale to measure the program’s impact. The results showed that existing curricula and practices tend to rely on a limited range of artistic activities, with an emphasis on developing social skills while giving less attention to cognitive and emotional dimensions. The intervention program demonstrated a clear positive impact, yielding statistically significant improvements among participants. Notably, gender differences emerged, as girls showed higher levels of progress following the program’s implementation.